She slipped into a coma and never regained consciousness.
Her family confirmed her death last night. on Thursday evening.
The New York State health department is now investigating the Yorkville Endoscopy clinic, where it has been claimed Rivers was given the same drug that was part of the cocktail of medications that killed as the King of Pop before his death in 2009.
RadarOnline reported that the Fashion Police presenter was given the drug propofol proposal, which is often used as an anaesthetic during surgery.
“Certainly, they suspect the anaesthesia was the issue, based on conversations between the staff and city medics,” a source close to the probe told the website.
Last Thursday, Rivers was rushed to Mount Sinai Hospital following her cardiac arrest.
She was put on a life support machine as doctors feared the worst but she was later moved from in intensive care and later moved to a private room, where her family said on Wednesday she was "kept comfortable".
Yesterday her daughter Melissa Rivers confirmed that her mother had passed away ‘surrounded by family and friends.’ "surrounded by family and friends".
She added: "My mother’s greatest joy in life was to make people laugh.
"Although that is difficult to do right now, I know her final wish would be that we return to laughing soon."
The gossip columnist talked of how she wanted her funeral to be a "huge showbiz affair" in her 2012 book, saying how she wanted actress Meryl Streep "crying in five different accents.
“I don’t want some rabbi rambling on; I want Meryl Streep crying, in five different accents.
She added: "I don’t want a eulogy; I want Bobby Vinton [60s US pop star] to pick up my head and sing ‘Mr. Lonely.’
“I want to be buried in a Valentino gown and I want Harry Winston to make me a toe tag. And I want a wind machine so that even in the casket my hair is blowing just like Beyoncé’s."
Reports have said Rivers’ funeral will take place on Sunday at Temple Emanu-El in Manhattan.
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